Compared with mouse thymocytes, mouse ES cells contain greater ranges of whole genomic H3K4me3 and have increased H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 46 In agreement with this, international decreases in H3K4me3 ranges happen during retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic changes in H3K4me3 profiles at particular units of genes during ES cell differentiation.
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